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Article

Mathematical Modeling Quantifies "Just-Right" APC Inactivation for Colorectal Cancer Initiation.

Cancer research - 15 Dec 2025

Brunet Guasch Meritxell, Feeley Nathalie A, Soriano Ignacio, Thorn Steve, Tomlinson Ian P M, Nicholson Michael D, Antal Tibor

Abstract excerpt

Dysregulation of the tumor suppressor gene adenomatous polyposis coli (APC) is a canonical step in colorectal cancer development by promoting activation of the WNT/β-catenin pathway. Curiously, most colorectal tumors carry biallelic mutations that result in only partial loss of APC function, suggesting that a "just-right" level of APC inactivation, and hence WNT signaling, provides the optimal conditions for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41091816
DOI: 10.1158/0008-5472.CAN-25-0445
PMCID: PMC7618390

Genes

APC
AMER1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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