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Article

Genome-wide association scan allowing for epistasis in type 2 diabetes.

Annals of human genetics - 1 Jan 2011

Bell Jordana T, Timpson Nicholas J, Rayner N William, Zeggini Eleftheria, Frayling Timothy M, Hattersley Andrew T, Morris Andrew P, McCarthy Mark I

Abstract excerpt

In the presence of epistasis multilocus association tests of human complex traits can provide powerful methods to detect susceptibility variants. We undertook multilocus analyses in 1924 type 2 diabetes cases and 2938 controls from the Wellcome Trust Case Control Consortium (WTCCC). We performed a two-dimensional genome-wide association (GWA) scan using joint two-locus tests of association including main and...

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Topics

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Share to Diabetes Mellitus, Type 2
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDKAL1 gene

Share to FTO gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 21133856
DOI: 10.1111/j.1469-1809.2010.00629.x
PMCID: PMC3430851

Genes

CDKAL1
FTO
TSPAN8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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