Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

doi:10.1086/520599

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Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.

American journal of human genetics - 1 Aug 2007

Salonen Jukka T, Uimari Pekka, Aalto Juha-Matti, Pirskanen Mia, Kaikkonen Jari, Todorova Boryana, Hyppönen Jelena, Korhonen Veli-Pekka, Asikainen Janne, Devine Christopher, Tuomainen Tomi-Pekka, Luedemann Jan, Nauck Matthias, Kerner Wolfgang, Stephens Richard H, New John P, Ollier William E, Gibson J Martin, Payton Antony, Horan Michael A, Pendleton Neil, Mahoney Walt, Meyre David, Delplanque Jerôme, Froguel Philippe, Luzzatto Oren, Yakir Benjamin, Darvasi Ariel

Abstract excerpt

Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at...

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PMID: 17668382
DOI: 10.1086/520599
PMCID: PMC1950819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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