A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

doi:10.1126/science.1142382

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Article

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

Science (New York, N.Y.) - 1 Jun 2007

Scott Laura J, Mohlke Karen L, Bonnycastle Lori L, Willer Cristen J, Li Yun, Duren William L, Erdos Michael R, Stringham Heather M, Chines Peter S, Jackson Anne U, Prokunina-Olsson Ludmila, Ding Chia-Jen, Swift Amy J, Narisu Narisu, Hu Tianle, Pruim Randall, Xiao Rui, Li Xiao-Yi, Conneely Karen N, Riebow Nancy L, Sprau Andrew G, Tong Maurine, White Peggy P, Hetrick Kurt N, Barnhart Michael W, Bark Craig W, Goldstein Janet L, Watkins Lee, Xiang Fang, Saramies Jouko, Buchanan Thomas A, Watanabe Richard M, Valle Timo T, Kinnunen Leena, Abecasis Gonçalo R, Pugh Elizabeth W, Doheny Kimberly F, Bergman Richard N, Tuomilehto Jaakko, Collins Francis S, Boehnke Michael

Abstract excerpt

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide poly...

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Identifiers

PMID: 17463248
DOI: 10.1126/science.1142382
PMCID: PMC3214617

Genes

CDKAL1
FTO
HHEX
KCNJ11
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17463248-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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