Article
The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium.
Diabetes - 1 Apr 2021
Srinivasan Shylaja, Chen Ling, Todd Jennifer, Divers Jasmin, Gidding Samuel, Chernausek Steven, Gubitosi-Klug Rose A, Kelsey Megan M, Shah Rachana, Black Mary Helen, Wagenknecht Lynne E, Manning Alisa, Flannick Jason, Imperatore Giuseppina, Mercader Josep M, Dabelea Dana, Florez Jose C
Abstract excerpt
The prevalence of type 2 diabetes in youth has increased substantially, yet the genetic underpinnings remain largely unexplored. To identify genetic variants predisposing to youth-onset type 2 diabetes, we formed ProDiGY, a multiethnic collaboration of three studies (TODAY, SEARCH, and T2D-GENES) with 3,006 youth case subjects with type 2 diabetes (mean age 15.1 ± 2.9 years) and 6,061 diabetes-free adult control...
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