Article
Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes.
Diabetes - 1 Mar 2022
O'Connor Mark J, Schroeder Philip, Huerta-Chagoya Alicia, Cortés-Sánchez Paula, Bonàs-Guarch Silvía, Guindo-Martínez Marta, Cole Joanne B, Kaur Varinderpal, Torrents David, Veerapen Kumar, Grarup Niels, Kurki Mitja, Rundsten Carsten F, Pedersen Oluf, Brandslund Ivan, Linneberg Allan, Hansen Torben, Leong Aaron, Florez Jose C, Mercader Josep M
Abstract excerpt
Most genome-wide association studies (GWAS) of complex traits are performed using models with additive allelic effects. Hundreds of loci associated with type 2 diabetes have been identified using this approach. Additive models, however, can miss loci with recessive effects, thereby leaving potentially important genes undiscovered. We conducted the largest GWAS meta-analysis using a recessive model for type 2...
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