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Article

Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants.

The FEBS journal - 1 May 2006

Aggelidou Eleni, Iordanidou Panagiota, Demetriades Constantinos, Piltsi Olga, Hadzopoulou-Cladaras Margarita

Abstract excerpt

Hepatocyte nuclear factor-4 (HNF-4alpha), a member of the nuclear receptor superfamily, binds DNA exclusively as a homodimer. Dimerization controls important aspects of receptor function, such as DNA binding, protein stability, ligand binding and interaction with coactivators. Crystallographic data of the HNF-4alpha ligand-binding domain (LBD) demonstrated that the homodimer interface is composed of residues in...

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PMID: 16640558
DOI: 10.1111/j.1742-4658.2006.05208.x

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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