Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structure-function relationship in a beta-sheet peptide inhibitor of E47 dimerization and DNA binding.

Bioorganic & medicinal chemistry - 1 Jan 1999

Ghosh I, Issac R, Chmielewski J

Abstract excerpt

A beta-sheet peptide inhibitor, 2H10, has been developed that inhibits the dimerization of the transcription factor E47. Inhibition of E47 dimerization has been demonstrated to also inhibit the DNA binding of this transcription factor. Truncated peptides based on 2H10 have demonstrated that the beta-sheet content of these peptides directly correlates with their inhibitory properties. Individual residues within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Dimerization
Share to Oligopeptides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptides

Share to Protein Structure, Secondary

Share to Spectroscopy, Fourier Transform Infrared

Share to Structure-Activity Relationship

Share to TCF Transcription Factors

Source

Identifiers

PMID: 10199656
DOI: 10.1016/s0968-0896(98)00214-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Structure-function relationship in a beta-sheet peptide inhibitor of E47 dimerization and DNA binding.PMID 10199656Read ↗

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.Semantic proximity Read ↗

Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil.Semantic proximity Read ↗

A versatile expression vector for the in vitro study of protein-protein interactions: characterization of E47 mutant proteins.Semantic proximity Read ↗

Selective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.Semantic proximity Read ↗

Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.Semantic proximity Read ↗

Structure function analysis of interleukin 7: requirement for an aromatic ring at position 143 of helix D.Semantic proximity Read ↗

Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.Semantic proximity Read ↗

Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.