Article
Buried asparagines determine the dimerization specificities of leucine zipper mutants.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997
Zeng X, Herndon A M, Hu J C
Abstract excerpt
Regulation of gene expression by many transcription factors is controlled by specific combinations of homo- and heterodimers through a short alpha-helical coiled-coil known as a leucine zipper. The dimer interface of a leucine zipper involves side chains of the residues at the a, d, e, and g positions of the (abcdefg)n heptad repeat. To understand the basis for the specificity of dimer formation, we characterized...
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