Article
Delineation of a 16 amino acid sequence that forms a core DNA recognition motif in the Epstein-Barr virus EBNA-1 protein.
Virology - 1 Dec 1994
Chen M R, Zong J, Hayward S D
Abstract excerpt
EBNA-1 is the sole virally specified protein required for replication of the Epstein-Barr virus latency origin and also modulates its own expression. Both of these functions are mediated through specific DNA binding. We created a series of amino acid substitutions across the previously identified...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Viral
- Base Sequence
- Binding Sites
- Cell Line
- DNA, Viral
- DNA-Binding Proteins
- Epstein-Barr Virus Nuclear Antigens
- Haplorhini
- Herpesvirus 4, Human
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- Replication Origin
- Trans-Activators
- Viral Proteins