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Article

E-box variants direct formation of distinct complexes with the basic helix-loop-helix protein ALF1.

Journal of molecular biology - 9 Jun 1995

Bonven B J, Nielsen A L, Nørby P L, Pedersen F S, Jørgensen P

Abstract excerpt

The murine transcription factor ALF1 belongs to the class of basic helix-loop-helix proteins specific for the NCAGNTGN-version of the E-box. Binding of homodimeric ALF1 to variants of this motif was studied by a combination of binding site selection technology and DNA modification interference analysis. The results showed that substitutions at the non-conserved positions in the E-box sequence could cause profound...

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PMID: 7783212
DOI: 10.1006/jmbi.1995.0319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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