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Article

Structure function analysis of interleukin 7: requirement for an aromatic ring at position 143 of helix D.

Cytokine - 7 Mar 2002

vanderSpek Johanna C, Sutherland John A, Gill Brian M, Gorgun Gullu, Foss Francine M, Murphy John R

Abstract excerpt

The residues located at the carboxyl terminus of helix D in interleukin-7 (IL-7) have previously been targeted as important for recruitment and binding to the gamma chain component of the IL-7 receptor (IL-7R). In this study, Trp 143 of helix D was mutated to His, Phe, Tyr and Pro and these mutan...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12027403
DOI: 10.1006/cyto.2002.1004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12027403-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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