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Article

On the mechanism of chloroquine resistance in Plasmodium falciparum.

PloS one - 19 Nov 2010

Chinappi Mauro, Via Allegra, Marcatili Paolo, Tramontano Anna

Abstract excerpt

Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a scientific debate. We...

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Identifiers

PMID: 21124966
DOI: 10.1371/journal.pone.0014064
PMCID: PMC2988812

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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