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Article

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.

Scientific reports - 11 Sept 2018

Lee Andrew H, Dhingra Satish K, Lewis Ian A, Singh Maneesh K, Siriwardana Amila, Dalal Seema, Rubiano Kelly, Klein Matthias S, Baska Katelynn S, Krishna Sanjeev, Klemba Michael, Roepe Paul D, Llinás Manuel, Garcia Celia R S, Fidock David A

Abstract excerpt

Plasmodium falciparum multidrug resistance constitutes a major obstacle to the global malaria elimination campaign. Specific mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediate resistance to the 4-aminoquinoline drug chloroquine and impact parasite susceptibility to several partner agents used in current artemisinin-based combination therapies, including amodiaquine. By...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30206341
DOI: 10.1038/s41598-018-31715-9
PMCID: PMC6134138

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