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Article

Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum.

Molecular microbiology - 1 Apr 2007

Sanchez Cecilia P, Rohrbach Petra, McLean Jeremy E, Fidock David A, Stein Wilfred D, Lanzer Michael

Abstract excerpt

The mechanism underpinning chloroquine drug resistance in the human malarial parasite Plasmodium falciparum has remained controversial. Currently discussed models include a carrier or a channel for chloroquine, the former actively expelling the drug, the latter facilitating its passive diffusion, out of the parasite's food vacuole, where chloroquine accumulates and inhibits haem detoxification. Here we have...

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Identifiers

PMID: 17493125
DOI: 10.1111/j.1365-2958.2007.05664.x
PMCID: PMC2944662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum.PMID 17493125Read ↗

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