Article
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.
The Journal of biological chemistry - 29 Aug 2003
Waller Karena L, Muhle Rebecca A, Ursos Lyann M, Horrocks Paul, Verdier-Pinard Dominik, Sidhu Amar Bir Singh, Fujioka Hisashi, Roepe Paul D, Fidock David A
Abstract excerpt
Plasmodium falciparum malaria is increasingly difficult to treat and control due to the emergence of parasite resistance to the major antimalarials, notably chloroquine. Recent work has shown that the chloroquine resistance phenotype can be conferred by multiple amino acid mutations in the parasite digestive vacuole transmembrane protein PfCRT. Here, we have addressed whether chloroquine resistance can also be...
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