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Article

PfCRT-mediated drug transport in malarial parasites.

Biochemistry - 18 Jan 2011

Roepe Paul D

Abstract excerpt

A wide range of drug transport studies using intact infected red blood cells, isolated malarial parasites, heterologous expression systems, and purified protein, combined with elegant genetic experiments, have suggested that chloroquine transport by the Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key aspect of the molecular mechanism of quinoline antimalarial drug resistance. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21142008
DOI: 10.1021/bi101638n
PMCID: PMC3123679

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