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Article

Structural and evolutionary analyses of the Plasmodium falciparum chloroquine resistance transporter.

Scientific reports - 16 Mar 2020

Coppée Romain, Sabbagh Audrey, Clain Jérôme

Abstract excerpt

Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) confer resistance to several antimalarial drugs such as chloroquine (CQ) or piperaquine (PPQ), a partner molecule in current artemisinin-based combination therapies. As a member of the Drug/Metabolite Transporter (DMT) superfamily, the vacuolar transporter PfCRT may translocate substrate molecule(s) across the membrane of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32179795
DOI: 10.1038/s41598-020-61181-1
PMCID: PMC7076037

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