Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum

18 Jul 2022

Abstract excerpt

The chloroquine resistance transporter, PfCRT, is important for the survival of the human malaria parasite Plasmodium falciparum. It increases the tolerance to many antimalarial drugs, and it is essential for the development of the parasite within red blood cells. While we understand the role of PfCRT in drug resistance in ever increasing detail, the non-drug resistance functions are still debated. Identifying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to Drug Transport and Resistance Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35867395
DOI: 10.1128/spectrum.01101-22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparumPMID 35867395Read ↗

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology.Semantic proximity Read ↗

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.Semantic proximity Read ↗

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.Semantic proximity Read ↗

Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.Semantic proximity Read ↗

PfCRT-mediated drug transport in malarial parasites.Semantic proximity Read ↗

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.Semantic proximity Read ↗

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.Semantic proximity Read ↗

PfCRT and its role in antimalarial drug resistance.Semantic proximity Read ↗

Structural and evolutionary analyses of the Plasmodium falciparum chloroquine resistance transporter.Semantic proximity Read ↗

Evidence for Activation of Endogenous Transporters in Xenopus laevis Oocytes Expressing the Plasmodium falciparum Chloroquine Resistance Transporter, PfCRTSemantic proximity Read ↗

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Semantic proximity Read ↗

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.