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Article

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.

Biochemistry - 6 Jul 2004

Zhang Hanbang, Paguio Michelle, Roepe Paul D

Abstract excerpt

Recently, mutations in the novel polytopic integral membrane protein PfCRT were shown to cause chloroquine resistance (CQR) in the malarial parasite Plasmodium falciparum. PfCRT is not a member of the well-known family of ABC proteins that have previously been associated with other drug resistance phenomena. Thus, the mechanism(s) whereby mutant PfCRT molecules confer antimalarial drug resistance is (are)...

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PMID: 15222741
DOI: 10.1021/bi049137i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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