Article
Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice.
The Journal of biological chemistry - 4 Feb 2011
Yano Masato, Watanabe Ken, Yamamoto Tadashi, Ikeda Kazutaka, Senokuchi Takafumi, Lu Meihong, Kadomatsu Tsuyoshi, Tsukano Hiroto, Ikawa Masahito, Okabe Masaru, Yamaoka Shohei, Okazaki Toshiro, Umehara Hisanori, Gotoh Tomomi, Song Wen-Jie, Node Koichi, Taguchi Ryo, Yamagata Kazuya, Oike Yuichi
Abstract excerpt
Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Here, we generated and analyzed SMS1-null mice. SMS1-null mice exhibited moderate neonatal lethality, reduced body weight, and loss of fat tissues mass, suggesting that they might have metabolic abnormality. Indeed, analysis on glucose metabolism revealed that they showed severe deficiencies in insulin secretion. Isolated...
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