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Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes

28 May 2020

Abstract excerpt

Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood–retinal barriers (BRB) is known to precede the initial BRB breakdown and further histopathological abnormalities in diabetic retinopathy (DR). We previously demonstrated that activation of acid sphingomyelinase (ASM) is an important early event in the pathogenesis of DR, and recent...

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PMID: 32481596
DOI: 10.3390/ijms21113830

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