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Article

Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function.

Scientific reports - 7 Mar 2016

Burkart Alison M, Tan Kelly, Warren Laura, Iovino Salvatore, Hughes Katelyn J, Kahn C Ronald, Patti Mary-Elizabeth

Abstract excerpt

Insulin resistance, a critical component of type 2 diabetes (T2D), precedes and predicts T2D onset. T2D is also associated with mitochondrial dysfunction. To define the cause-effect relationship between insulin resistance and mitochondrial dysfunction, we compared mitochondrial metabolism in induced pluripotent stem cells (iPSC) from 5 healthy individuals and 4 patients with genetic insulin resistance due to...

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Identifiers

PMID: 26948272
DOI: 10.1038/srep22788
PMCID: PMC4780029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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