Article
The mitochondrial Atp8 mutation induces mitochondrial ROS generation, secretory dysfunction, and β-cell mass adaptation in conplastic B6-mtFVB mice.
Endocrinology - 1 Oct 2012
Weiss Heike, Wester-Rosenloef Lena, Koch Christiane, Koch Franziska, Baltrusch Simone, Tiedge Markus, Ibrahim Saleh
Abstract excerpt
Mutations in mitochondrial DNA (mtDNA) cause a variety of pathologic phenotypes. In this study, we used conplastic mouse strains to characterize the impact of a mtDNA mutation in the Atp8 gene on β-cell function, reactive oxygen species (ROS) generation, β-cell mass, and glucose metabolism in response to high-fat diet (HFD). In comparison with B6-mt(AKR) controls, the B6-mt(FVB) strain carries a point mutation of...
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