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Article

Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice.

PloS one - 1 Jan 2013

Yano Masato, Yamamoto Tadashi, Nishimura Naotaka, Gotoh Tomomi, Watanabe Ken, Ikeda Kazutaka, Garan Yohei, Taguchi Ryo, Node Koichi, Okazaki Toshiro, Oike Yuichi

Abstract excerpt

Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin. Here, we found that SMS1 null mice showed lipodystrophic phenotype. Mutant mice showed up-regulation of plasma triglyceride concentrations accompanied by reduction of white adipose tissue (WAT) as they aged. Lipoprotein lipase (LPL) activity was severely reduced in mutant mice. In vivo analysis indicated that fatty acid uptake...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23593476
DOI: 10.1371/journal.pone.0061380
PMCID: PMC3625169

Genes

LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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