Article

Effects of Ceramide Accumulation in Cardiomyocytes Derived from human-induced Pluripotent Stem Cells on Mitochondrial Function and Mitophagy

2020-08-05

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Oversupply of fatty acids (FAs) to cardiomyocytes (CMs) is associated with increased ceramide content and elevated the risk of lipotoxic cardiomyopathy.<bold> </bold>Here we investigate the role of ceramide accumulation on mitochondrial function and mitophagy in cardiac lipotoxicity using CMs derived from human-induced pluripotent stem cells (h-iPSCs). <bold>Metho...

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Literature Corpus work: 8ffa30a0-6163-5a6e-8d57-70d19b8a0426
DOI: 10.21203/rs.3.rs-47563/v1

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