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Article

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.

The AAPS journal - 1 Apr 2013

Motohashi Hideyuki, Inui Ken-ichi

Abstract excerpt

In the kidney, human organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) are the major transporters for the secretion of cationic drugs into the urine. In the human kidney, OCT2 mediates the uptake of drugs from the blood at the basolateral membrane of tubular epithelial cells, and MATE1 and MATE2-K secrete drugs from cells into the lumen of proximal tubules. However, the...

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Identifiers

PMID: 23435786
DOI: 10.1208/s12248-013-9465-7
PMCID: PMC3675737

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