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Article

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.

American journal of physiology. Renal physiology - 1 Apr 2010

Meyer zu Schwabedissen Henriette E, Verstuyft Celine, Kroemer Heyo K, Becquemont Laurent, Kim Richard B

Abstract excerpt

Renal elimination of a number of cationic compounds is thought to be mediated by the organic cation transporter 2 (OCT2, SLC22A2), a drug uptake transporter expressed at the basolateral domain of renal tubular cells. Recently, the key efflux transporter for the secretion organic cations was identified as an electroneutral H(+)/organic cation exchanger termed the multidrug and toxin extrusion (MATE)-type...

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PMID: 20053795
DOI: 10.1152/ajprenal.00431.2009

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Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms.PMID 20053795Read ↗

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Semantic proximity Read ↗

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics.Semantic proximity Read ↗

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Semantic proximity Read ↗

Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics.Semantic proximity Read ↗

Identification and functional characterization of novel nonsynonymous variants in the human multidrug and toxin extrusion 2-K.Semantic proximity Read ↗

Genetic variation in organic cation transporters and considerations in drug development.Semantic proximity Read ↗

Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study.Semantic proximity Read ↗

Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.Semantic proximity Read ↗

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function.Semantic proximity Read ↗

Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants.Semantic proximity Read ↗

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