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Article

Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.

PloS one - 12 Nov 2010

Lan Lan, Lin Shengyin, Zhang Sui, Cohen Robert S

Abstract excerpt

The Drosophila melanogaster gurken gene encodes a TGF alpha-like signaling molecule that is secreted from the oocyte during two distinct stages of oogenesis to define the coordinate axes of the follicle cell epithelium that surrounds the oocyte and its 15 anterior nurse cells. Because the gurken receptor is expressed throughout the epithelium, axial patterning requires region-specific secretion of Gurken protein,...

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Identifiers

PMID: 21103393
DOI: 10.1371/journal.pone.0015448
PMCID: PMC2980492

Genes

GLS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.PMID 21103393Read ↗

The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte.Semantic proximity Read ↗

Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg.Semantic proximity Read ↗

maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA.Semantic proximity Read ↗

Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes.Semantic proximity Read ↗

Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila.Semantic proximity Read ↗

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.Semantic proximity Read ↗

spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila.Semantic proximity Read ↗

The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila.Semantic proximity Read ↗

A genetic screen based on in vivo RNA imaging reveals centrosome-independent mechanisms for localizing gurken transcripts in Drosophila.Semantic proximity Read ↗

The dynamics of fluorescently labeled endogenous gurken mRNA in Drosophila.Semantic proximity Read ↗

The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization.Semantic proximity Read ↗

Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.Semantic proximity Read ↗

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