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Article

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

Cell - 8 Oct 1993

Neuman-Silberberg F S, Schüpbach T

Abstract excerpt

Cell-cell interactions in the Drosophila ovary play a crucial role in the establishment of dorsoventral polarity of both the egg shell and the future embryo. Torpedo/DER (top/DER), a homolog of the vertebrate epidermal growth factor receptor, is required for this signaling process in the somatic cells of the ovary. In contrast, gurken (grk), which also functions in this pathway, is required in the germline. We...

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PMID: 7691414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.PMID 7691414Read ↗

Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila.Semantic proximity Read ↗

Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg.Semantic proximity Read ↗

The relationship between ovarian and embryonic dorsoventral patterning in Drosophila.Semantic proximity Read ↗

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila.Semantic proximity Read ↗

Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis.Semantic proximity Read ↗

Polarization of both major body axes in Drosophila by gurken-torpedo signalling.Semantic proximity Read ↗

The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila.Semantic proximity Read ↗

The angle of the dorsoventral axis with respect to the anteroposterior axis in the Drosophila embryo is controlled by the distribution of gurken mRNA in the oocyte.Semantic proximity Read ↗

Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.Semantic proximity Read ↗

maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA.Semantic proximity Read ↗

The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte.Semantic proximity Read ↗

Functioning of the Drosophila orb gene in gurken mRNA localization and translation.Semantic proximity Read ↗

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