Article
The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila.
Mechanisms of development - 1 Dec 1999
Queenan A M, Barcelo G, Van Buskirk C, Schüpbach T
Abstract excerpt
During Drosophila oogenesis, localization of the transforming growth factor alpha (TGFalpha)-like signaling molecule Gurken to the oocyte membrane is required for polarity establishment of the egg and embryo. To test Gurken domain functions, full-length and truncated forms of Gurken were expressed ectopically using the UAS/Gal4 expression system, or in the germline using the endogenous promoter. GrkDeltaC, a...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Biological Transport
- Cell Membrane
- Drosophila
- Drosophila Proteins
- ErbB Receptors
- Female
- Insect Proteins
- Molecular Sequence Data
- Mutation
- Oocytes
- Transforming Growth Factor alpha
- Transforming Growth Factors