Article
Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.
Developmental biology - 15 Jan 2013
Tian Ai-Guo, Tamori Yoichiro, Huang Yi-Chun, Melendez Natalia Toledo, Deng Wu-Min
Abstract excerpt
Vesicle trafficking plays a crucial role in the establishment of cell polarity in various cellular contexts, including axis-pattern formation in the developing egg chamber of Drosophila. The EGFR ligand, Gurken (Grk), is first localized at the posterior of young oocytes for anterior-posterior axis formation and later in the dorsal anterior region for induction of the dorsal-ventral (DV) axis, but regulation of...
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