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Article

Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies.

PloS one - 17 Nov 2010

So Hon-Cheong, Yip Benjamin H K, Sham Pak Chung

Abstract excerpt

Recently genome-wide association studies (GWAS) have identified numerous susceptibility variants for complex diseases. In this study we proposed several approaches to estimate the total number of variants underlying these diseases. We assume that the variance explained by genetic markers (Vg) follow an exponential distribution, which is justified by previous studies on theories of adaptation. Our aim is to fit...

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Identifiers

PMID: 21103334
DOI: 10.1371/journal.pone.0013898
PMCID: PMC2984437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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