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Article

Measuring missing heritability: inferring the contribution of common variants.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Golan David, Lander Eric S, Rosset Saharon

Abstract excerpt

Genome-wide association studies (GWASs), also called common variant association studies (CVASs), have uncovered thousands of genetic variants associated with hundreds of diseases. However, the variants that reach statistical significance typically explain only a small fraction of the heritability. One explanation for the "missing heritability" is that there are many additional disease-associated common variants...

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Identifiers

PMID: 25422463
DOI: 10.1073/pnas.1419064111
PMCID: PMC4267399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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