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Article

How many genetic variants remain to be discovered?

PloS one - 2 Dec 2009

Pawitan Yudi, Seng Ku Chee, Magnusson Patrik K E

Abstract excerpt

A great majority of genetic markers discovered in recent genome-wide association studies have small effect sizes, and they explain only a small fraction of the genetic contribution to the diseases. How many more variants can we expect to discover and what study sizes are needed? We derive the connection between the cumulative risk of the SNP variants to the latent genetic risk model and heritability of the...

Topics

Case-Control Studies
Diabetes Mellitus, Type 2
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Inheritance Patterns
Models, Genetic
Odds Ratio
Polymorphism, Single Nucleotide
Sample Size

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Identifiers

PMID: 19956539
DOI: 10.1371/journal.pone.0007969
PMCID: PMC2780697

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