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Article

Model-Based Multifactor Dimensionality Reduction for Rare Variant Association Analysis.

Human heredity - 1 Jan 2015

Fouladi Ramouna, Bessonov Kyrylo, Van Lishout François, Van Steen Kristel

Abstract excerpt

Genome-wide association studies have revealed a vast amount of common loci associated to human complex diseases. Still, a large proportion of heritability remains unexplained. The extent to which rare genetic variants (RVs) are able to explain a relevant portion of the genetic heritability for complex traits leaves room for several debates and paves the way to the collection of RV databases and the development of...

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PMID: 26201701
DOI: 10.1159/000381286

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