Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.

doi:10.1016/j.neures.2013.08.010

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Article

Association analysis of the DISC1 gene with schizophrenia in the Japanese population and DISC1 immunoreactivity in the postmortem brain.

Neuroscience research - 1 Dec 2013

Ratta-Apha Woraphat, Hishimoto Akitoyo, Mouri Kentaro, Shiroiwa Kyoichi, Sasada Toru, Yoshida Masakuni, Supriyanto Irwan, Ueno Yasuhiro, Asano Migiwa, Shirakawa Osamu, Togashi Hideru, Takai Yoshimi, Sora Ichiro

Abstract excerpt

The Disrupted-in-Schizophrenia 1 (DISC1) gene plays a role in the regulation of neural development. Previous evidence from genetic association and biological studies implicates the DISC1 gene as having a role in the pathophysiology of schizophrenia. In the present study, we explored the association between DISC1 missense mutation rs821616 (Ser704Cys) single nucleotide polymorphism (SNP) and four other SNPs...

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Identifiers

PMID: 24013095
DOI: 10.1016/j.neures.2013.08.010

Genes

DISC1

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