Article
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Blood - 1 Sept 2011
Pronier Elodie, Almire Carole, Mokrani Hayat, Vasanthakumar Aparna, Simon Audrey, da Costa Reis Monte Mor Barbara, Massé Aline, Le Couédic Jean-Pierre, Pendino Frédéric, Carbonne Bruno, Larghero Jérôme, Ravanat Jean-Luc, Casadevall Nicole, Bernard Olivier A, Droin Nathalie, Solary Eric, Godley Lucy A, Vainchenker William, Plo Isabelle, Delhommeau François
Abstract excerpt
TET2 converts 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC) in DNA and is frequently mutated in myeloid malignancies, including myeloproliferative neoplasms. Here we show that the level of 5-hmC is decreased in granulocyte DNA from myeloproliferative neoplasm patients with TET2 mutations co...
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