Article
Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors.
The international journal of biochemistry & cell biology - 1 Jan 2011
Levy Claudia B, Stumbo Ana C, Ano Bom Ana P D, Portari Elisabeth A, Cordeiro Yraima, Carneiro Yraima, Silva Jerson L, De Moura-Gallo Claudia V
Abstract excerpt
P53 is one of the most important tumor suppressor proteins in human cancers. Mutations in the TP53 gene are common features of malignant tumors and normally correlate to a more aggressive disease. In breast cancer, these gene alterations are present in approximately 20% of cases and are characteristically of missense type. In the present work we describe TP53 mutations in breast cancer biopsies and investigate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.