Article
The aggregation of mutant p53 produces prion-like properties in cancer.
Prion - 1 Jan 2000
Rangel Luciana P, Costa Danielly C F, Vieira Tuane C R G, Silva Jerson L
Abstract excerpt
The tumor suppressor protein p53 loses its function in more than 50% of human malignant tumors. Recent studies have suggested that mutant p53 can form aggregates that are related to loss-of-function effects, negative dominance and gain-of-function effects and cancers with a worsened prognosis. In recent years, several degenerative diseases have been shown to have prion-like properties similar to mammalian prion...
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