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Amyloidogenicity of p53: A Hidden Link Between Protein Misfolding and Cancer

28 Nov 2014

Abstract excerpt

Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitusand Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulates the cell cycle and apoptosis, is also amyloidogenic. In tumor models, both wild type and mutant...

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PMID: 25440023
DOI: 10.2174/1389203715666141128115649

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