Article

Induction of intracellular wild-type p53 amyloids leading to cellular transformation and tumor formation in mice

2020-06-06

Abstract excerpt

Tumor suppressor p53 mutations, with subsequent loss-of-tumor suppressive function and gain-of oncogenic functions, are associated with more than 50% of human cancers. Aggregation and amyloid formation are also mechanisms by which wild type and mutant p53 might be involved in cancer, but the direct evidence of how aggregated p53 acts as an oncogene is lacking. In this study, we directly demonstrate that wild-type...

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Literature Corpus work: e3dbec00-e874-5cc1-bf17-d7e093ee7b0c
DOI: 10.1101/2020.06.04.133124

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