Article
Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor.
Bioscience reports - 25 Jul 2013
Silva Jerson L, Rangel Luciana P, Costa Danielly C F, Cordeiro Yraima, De Moura Gallo Claudia V
Abstract excerpt
p53 is a key protein that participates in cell-cycle control, and its malfunction can lead to cancer. This tumour suppressor protein has three main domains; the N-terminal transactivation domain, the CTD (C-terminal domain) and the core domain (p53C) that constitutes the sequence-specific DBD (DNA-binding region). Most p53 mutations related to cancer development are found in the DBD. Aggregation of p53 into...
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