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p53 amyloid aggregation in cancer: function, mechanism, and therapy

28 Sept 2022

Abstract excerpt

Abstract Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has been proposed in recent years. p53, the most well-known tumor suppressor, has been extensively studied for its expression, mutation, and function in various tumors. Currently, an interesting phenomenon of p53 prion-like aggregation has been found in several tumors, and studies have found that its pathological...

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PMID: 36171607
DOI: 10.1186/s40164-022-00317-7

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