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Article

Amyloidogenicity of p53: a hidden link between protein misfolding and cancer.

Current protein & peptide science - 1 Jan 2015

Gong Hao, Yang Xin, Zhao Yudan, Petersen Robert B, Liu Xinran, Liu Yang, Huang Kun

Abstract excerpt

Pathogenic aggregation is closely associated with various protein misfolding diseases such as type 2 diabetes mellitus and Alzheimer's disease. Amyloidogenic proteins that have a propensity to assemble into amyloid oligomers and fibrils form the aggregates. The tumor suppressor p53, a transcription factor that regulates the cell cycle and apoptosis, is also amyloidogenic. In tumor models, both wild type and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25692950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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