Article
Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium.
Oncogene - 1 Aug 2023
Heinzl Nicole, Maritschnegg Elisabeth, Koziel Katarzyna, Schilhart-Wallisch Christine, Heinze Georg, Yang Wei-Lei, Bast Robert C, Sehouli Jalid, Braicu Elena I, Vergote Ignace, Van Gorp Toon, Mahner Sven, Paspalj Valentina, Grimm Christoph, Obermayr Eva, Schuster Eva, Holzer Barbara, Rousseau Frederic, Schymkowitz Joost, Concin Nicole, Zeillinger Robert
Abstract excerpt
TP53 is the most commonly mutated gene in cancer and has been shown to form amyloid-like aggregates, similar to key proteins in neurodegenerative diseases. Nonetheless, the clinical implications of p53 aggregation remain unclear. Here, we investigated the presence and clinical relevance of p53 aggregates in serous ovarian cancer (OC). Using the p53-Seprion-ELISA, p53 aggregates were detected in 46 out of 81...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.