Article
Mutant p53 protein in serum could be used as a molecular marker in human breast cancer.
International journal of oncology - 1 Apr 2006
Balogh G A, Mailo D A, Corte M M, Roncoroni P, Nardi H, Vincent E, Martinez D, Cafasso M E, Frizza A, Ponce G, Vincent E, Barutta E, Lizarraga P, Lizarraga G, Monti C, Paolillo E, Vincent R, Quatroquio R, Grimi C, Maturi H, Aimale M, Spinsanti C, Montero H, Santiago J, Shulman L, Rivadulla M, Machiavelli M, Salum G, Cuevas M A, Picolini J, Gentili A, Gentili R, Mordoh J
Abstract excerpt
p53 wild-type is a tumor suppressor gene involved in DNA gene transcription or DNA repair mechanisms. When damage to DNA is unrepairable, p53 induces programmed cell death (apoptosis). The mutant p53 gene is the most frequent molecular alteration in human cancer, including breast cancer. Here, we analyzed the genetic alterations in p53 oncogene expression in 55 patients with breast cancer at different stages and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.