Article
p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis.
Cell death and differentiation - 1 Oct 2017
Ghosh Saikat, Salot Shimul, Sengupta Shinjinee, Navalkar Ambuja, Ghosh Dhiman, Jacob Reeba, Das Subhadeep, Kumar Rakesh, Jha Narendra Nath, Sahay Shruti, Mehra Surabhi, Mohite Ganesh M, Ghosh Santanu K, Kombrabail Mamata, Krishnamoorthy Guruswamy, Chaudhari Pradip, Maji Samir K
Abstract excerpt
The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where p53 often accumulates in the nucleus as well as in cytoplasm. Although it has been previously suggested that amyloid formation could be a cause of p53 loss-of-function in subset of tumors, the characterization of these amyloids and its structure-function...
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