Article
MDM2 as a modifier gene in retinoblastoma.
Journal of the National Cancer Institute - 1 Dec 2010
Castéra Laurent, Sabbagh Audrey, Dehainault Catherine, Michaux Dorothée, Mansuet-Lupo Audrey, Patillon Blandine, Lamar Estelle, Aerts Isabelle, Lumbroso-Le Rouic Livia, Couturier Jérôme, Stoppa-Lyonnet Dominique, Gauthier-Villars Marion, Houdayer Claude
Abstract excerpt
Variability in the age of onset and number of tumors is occasionally described among retinoblastoma patients, and possible genetic modifiers might lie in the pRB or p53 pathways, both of which are involved in the development of retinoblastoma. MDM2, which increases p53 and pRB catabolism, is therefore a prominent candidate. The minor allele of MDM2 that includes a 309T>G transversion (single-nucleotide...
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