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Article

A diabetes-induced change of MDM2 SNP309T→G contributes to aberrant retinal angiogenesis.

Diabetologia - 1 Jun 2026

Ma Gaoen, Wu Wenyi, Duan Yajian, Yang Yanhui, Huang Xionggao, Pang Zhuo, Jiang Heng, Ma Junkai, Yuan Fang, Zhou Guohong, Vanhaesebroeck Bart, Luo Jing, Yan Xiaohe, Lei Hetian

Abstract excerpt

AIMS/HYPOTHESIS: The 309G SNP in the second promoter of the gene encoding mouse double minute 2 (MDM2) has been implicated in multiple human diseases. The aims of this study were to determine whether MDM2 SNP309G is associated with proliferative diabetic retinopathy (PDR), and whether it contributes to pathological angiogenesis. METHODS: Sanger DNA sequencing was used to determine the MDM2 SNP309 status in...

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Share to Diabetic Retinopathy
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Neovascularization, Pathologic

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-mdm2

Share to Retina

Share to Retinal Neovascularization

Source

Identifiers

PMID: 41770245
DOI: 10.1007/s00125-026-06695-5

Genes

MDM2
PVR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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A diabetes-induced change of MDM2 SNP309T→G contributes to aberrant retinal angiogenesis.PMID 41770245Read ↗

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